I have a V2200 and love it. Big, heavy, industrial-looking player that will probably outlive my other equipment. That said, yes, there will be some limitations on what can be watched on it. However, more than likely you'll be fine with 90%+ of your collection. Out of 61 titles I own, I'm limited by analog audio output only on these films:
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E.T. The Extra-Terrestrial: Limited Edition (1982) [42734] - The analog audio track is only the score, no spoken dialog. This affects only the main feature, as the extras have full analog audio available.
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Ghost in the Shell: Premium Box (1995) [BEAL-921] - The digital track is Japanese, where the analog is in English. As I don't speak Japanese and the film did not include subtitles/closed-captions, this is more of a blessing than anything.
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Boot, Das (The Boat) (1981) [79346] - Similar to Ghost in the Shell, digital tracks are in German, analog is English. I guess this one is subjective, as someone may prefer watching it with English dubs, but personally I'd rather watch it with the German audio (it includes burned-in English subtitles).
Overall, its uncommon for a Laserdisc title to not include a copy of the full audio on at least one of the analog tracks. Check the database for films you're concerned about. This is not a player you would probably want to hook up to your nice hi-fi system with 5.1, but if you're like me and want a player in your home office hooked up to a small TV set, this is an excellent option.